2 edition of Kinetic studies of aggregation and solubilisation of drugs by ultrasonic methods. found in the catalog.
Kinetic studies of aggregation and solubilisation of drugs by ultrasonic methods.
Santosh Kumari Sharma
PhD thesis, Chemistry.
As a result of the pioneering efforts of Eigen, de Maeyer, Norrish and Porter, the kinetics of fast reactions in solution can now be studied using chemical relaxation methods, as well as many other fast reactions techniques. These methods have been applied successfully in many branches of the. The aim of this study was to assess the in vitro release kinetics of antituberculosis drug-loaded nanoparticles (NPs) using a “modified” cylindrical apparatus fitted with a regenerated cellulose membrane attached to a standard dissolution apparatus (modifiedcylinder method). The model drugs that were used were rifampicin (RIF) and moxifloxacin hydrochloride (MX).
So far many techniques have been used to increase the solubility and therefore the dissolution rate of poorly water soluble drugs. Methods such as cosolvency and microemulsion techniques , crystal habit modification, complexation , formulation in proper salt form [32, 33], preparation of solid dispersion [8, ], liquisolid. Get this from a library! Techniques and Applications of Fast Reactions in Solution: Proceedings of the NATO Advanced Study Institute on New Applications of Chemical Relaxation Spectrometry and Other Fast Reaction Methods in Solution, held at the University College of Wales, Aberystwyth, September , [W J Gettins; E Wyn-Jones] -- As a result of the .
A large number of studies have investigated aggregation behavior and determined the CMC values of MCFAs using different experimental techniques such as surface tension measurement, the dye micellization method, the relative viscosity-based method, high resolution ultrasonic spectroscopy, ion activity measurement, and conductimetry. aggregation is primarily due to the lack of a concrete understanding of the aggregation process. Kinetic studies and data curve fitting are keys to rigorous mechanistic studies . When combined with experimental kinetic and thermodynamic data, models of aggregation .
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Kinetic studies of aggregation and solubilisation of drugs by ultrasonic methods. Author: Sharma, S. Ultrasonic relaxation studies in mixed micellar solutions of the surfactants sodium decylsulphate and dodecyltrimethylammonium bromide with n-pentanol have shown two well defined relaxations associated with the exchange process involving the partitioning of alcohol and also surfactant monomer with the mixed micelleCited by: 8.
Görkem Eskiizmir, Kerim Yapici, in Nanostructures for Oral Medicine, In vitro and in vivo studies. In an experimental oral SCC model, a biodegradable thermosensitive hydrogel, a drug carrier for tailoring drug release kinetics, was designed for the delivery of cisplatin, a highly cytotoxic anticancer drug, which is widely used for lung cancer, ovarian cancer, head and neck.
0 is the initial amount of drug in the solution (most times, Q 0 = 0) and K 0 is the zero order release con-stant expressed in units of concentration/time.
To study the release kinetics, data obtained from in vitro drug release studies were plotted as cumulative amount of drug released versus time (24, 25). Application: This relationship can be File Size: 65KB. Kinetic study of the aggregation of the oil-in-water emulsions by SdFFF.
• The advantages of SdFFF in studying the instability of the oil-in-water emulsions. • The effect of the emulsifier Tween 80 on the stability of the oil-in-water emulsions. • A mechanism for the aggregation of the oil-in-water emulsions is by: 3.
Studies for the solubilization of drugs such as haloperi- dol, indomethacin, doxorub icin (DOX), amphotericin B and digoxin have been reported (52, ) and a. kinetic solubility measurement at early drug discovery. The aim of this study is to design of a DMSO based solubility determination methods and find out the extent of validity of designed method with the shake flask method.
A DMSO based method is designed and solubility determined at pH and at 25 ºC for model compound. Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response.
Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic. INTRODUCTION: INTRODUCTION CHEMICAL KINETICS is the study of rate of chemical changes taking place during chemical reactions. As applied to pharmaceutical formulations, this includes a study of the physical and chemical reactions in drugs and dosage forms, factors influencing the rate of these chemical reactions, accelerated stability testing and prediction of.
A kinetic study of the aggregation and lipid mixing promoted by this protein on phosphatidylglycerol (PG) and phosphatidylserine (PS) vesicles has been performed. Egg yolk PG, bovine brain PS, dimyristoyl-PG (DMPG) and dimyristoyl-PS (DMPS) vesicles have been considered.
The initial rates of the vesicle aggregation induced by the protein have. the likelihood of drug aggregation, leading to poor absorption and and the kinetic stability of the micelle. The self-assembly of amphiphilic copolymers is a thermodynamic and, consequently, reversible process that is entropically driven by the either the arm-first or core-first methods.
In th-first method, e arm. Figure 4 Chemical kinetic analysis for drug discovery. The kinetic analysis of the aggregation mechanism in the presence and in the absence of a proposed inhibitor, together with its experimental characterization of the reaction rates, provides information about the microscopic inhibited events and targeted species.
Wyn-Jones's research works with 3, citations and 1, reads, including: Spectroscopic and acoustic measurements in relation to.
KINETIC STUDIES OF SOME ESTERS AND AMIDES IN PRESENCE OF MICELLES 55 | Page Chapter - 2 Critical Micelle Concentration of Surfactant, Mixed Surfactant and Polymer By Different Methods at Room Temperature And Its Importance Abstract Critical Micelle Concentration (CMC) is the key point for surface chemistry as.
spectively. Icagen’s typical implementation includes measurement of kinetic solubility in phosphate buﬀer at pH directly from 10 mM DMSO stock solution. For data processing, report generation, and to provide our customers with the detailed visual representation of data, we adapted the Jupyter Note-book supported by Python programming.
KINETIC STUDY OF DRUG ELIMINATION METHODS Chemical methods The following compounds were used as standards in the analytical procedures: (i) Paracetamol B.P.
(ii) Paracetamol sulphate, potassium salt monohydrate. Potassium p-nitrophenylsulphate was prepared by the method of Burkhardt &Wood() and reduced to the p.
Kinetic study on solubilization of pinacyanol chloride into the micelle of sodium dodecyl sulfate by a stopped-flow technique. Journal of Colloid and Interface Science47 (1), DOI: /(74) R.L Reeves, R.S Kaiser, H.W Mark. kinetic mechanisms of activity loss without further experimen-tation, very often empirical approaches are used in assessing suitable antibody modiﬁcations and formulations.
Typically, multiple methods are employed, often in a high-throughput format, The methods commonly used in such analyses. Structure-kinetic relationship studies are a successful strategy for the discovery of novel drugs Compounds with identical affinity for a given target can exhibit very different kinetic profiles, which may result in the differentiation of the clinical responses.
This phenomenon is exemplified with inhibitors of CDK8/Cyclin C. Medium chain fatty acids (MCFA) are digestion products of lipid-rich food and lipid-based formulations, and they are used as transient permeability enhancers in formulation of poorly permeable compounds. These molecules may promote drug absorption by several different processes, including solubilization, increased membrane fluidity, and increased paracellular.
Kinetic solubility is often the method of choice in drug discovery. It is fast, cost effective, suitable for high-throughput screening (HTS) and requires only a small amount of compound.
To determine kinetic solubility, compound is added to an aqueous buffer using a stock solution prepared in an organic solvent, usually DMSO.Juanhong Zhang, Junmin Zhang, Rong Wang, Zhengping Jia, Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes, Current Drug Metabolism, /, 20, 2, (), ().Techniques and Applications of Fast Reactions in Solution Proceedings of the NATO Advanced Study Institute on New Applications of Chemical Relaxation Spectrometry and Other Fast Reaction Methods in Solution, held at the University College of .